Thank you for your question.
Since it seems like you are using Autodesk Design Review as a platform to build your .Net application, I propose you use API IAdContent.set_Objects instead of IAdEPlotObjectNode.Selected to select an object.
For "how to programmatically select an object with ActiveX control", you can find detailed sample code from Autodesk Design Review
API documentation.
Please refer to the "Section.Content Property" section of this documentation for more information.
Please let me know if you have any follow-on questions.
-Herbert